Of course, at first this may seem like a rather complicated whole, but it is important to understand both parts and vicious circles well. Let's clarify step by step.

About 50% of us are securely attached and therefore 50% are insecurely attached. In the case of insecure attachment, reactions to behaviors of unsafe or absent parents arise in childhood. Your brain is still little developed so many reactions are emotional (crying, screaming, laughing, demanding attention). But if this doesn't work, the risk of repression arises (if I just don't cry, if I'm nice, if I try really hard .... etc. then I can be there).

The first seeds for developmental trauma have been laid. Suppression of emotions may create (systemic) stress and trauma in your body.

As you grow up with insecure attachment, you develop limiting beliefs (e.g. I'm not ok the way I am, I'm not worth being loved, I don't matter, I have to do everything myself or alone, I have to be tough, if I perform/successful then I'm allowed to be there, if there are problems I have to run away). You then mask these beliefs with other compensatory beliefs or other behaviors (being tough, over performing, pride, isolation, deviant eating behaviors, etc.).

* First vicious circle (yellow): suppression of emotions in early and later childhood can cause developmental trauma. Emotions, stored in you fascia and disturbing your FAL-Axis (Fascia-Autonomous Nervous System-Limbic Brain). But this trauma is also often reinforcing feelings of insecurity or unworthiness, so that new unhelpful or even limiting beliefs/standards and values can arise. Your nervous system is from your (early) childhood already more sensitive to stimuli because of this.

Subsequently, these (unconscious) limiting beliefs, hypersensitivity and trauma will affect your system during stressful moments in the rest of your life. Relationships that are unstable due to attachment or bonding anxiety or (trauma related), emotional reactions and hypersensitivity, or over performing at work, or tensions due to (often based on unconscious inferior feelings) egocentric or even narcissistic behavior. All of this creates continuous systemic stress.

External factors count “double”: Of course, trauma or stress and systemic disruption can also arise or increase in other ways. Experiences of violence and insecurity from where you grow up or later in life, accidents and intense emotional experiences can exacerbate trauma if you suppress emotions (and especially in the case of being insecurely attached). Events (death, illness, accidents or other very stressful events) can increase your systemic stress. In this sense, “fate” can also influence later (susceptibility to) chronic system diseases. But if your system was already under high stress because of your insecure attachment, the impact of these events may be higher.

* Second vicious circle (light red): life stress can have extra impact on your (body's) system due to lowered stress tolerance or precisely due to masking behavior and suppression of feelings and emotions. You unconsciously cause more stress for yourself (and others) in case of insecure attachment. This in turn can affect (exacerbate) your limiting beliefs and trauma. “The world is an unsafe place” ”relationships with .... are impossible” and deepening existing beliefs of unworthiness, unlovability, and performance obligation. (External and self-induced) Stress intensifies your inner pressure, and your mechanisms in turn cause more stress.

Because long-term negative (limiting) beliefs about yourself and others develop from your insecure attachment throughout your life, and you keep repeating them, preferential neural pathways for this (literally thicker nerve pathways) develop and you become more likely to think, interpret and project negative or limiting beliefs into the future. This in turn causes more pressure/stress on your own system (and often that of others).

* Third vicious circle (orange): Through negative neuroplasticity, you increase internal system pressure (stress) and thus the likelihood of (temporary) dysregulation of a multitude of internal processes. Temporary disturbances of your hypothalamic-pituitary-adrenal (HPA) axis (see block at the bottom of this article) and Autonomic Nervous System (ANS) (brake/gas pedal of your body) have to be compensated by your body which costs energy and creates system stress.

This is not necessarily a problem right away. Your system can repair itself. But due to (epi)genetic expression of your DNA, internal increased stress due to unsafe bonding, and external stress (due to work pressure, relationship stress, viruses, societal stress) you are increasingly at risk of temporary system dysregulation that lasts a bit longer and can cause temporary illness (Excess Fatigue, Overworked, Burnout, Depression, Emotional instability and increased risk of viral and bacterial problems such as colds, flu etc.).

It becomes more dangerous when stress is experienced long-term or very frequently. Chronic stress and trauma affect and disrupt the nervous and immune systems. The hypothalamic-pituitary-adrenal (HPA) axis and your ANS become dysregulated for long periods of time, leaving the body in a constant state of fight, flight or freeze. This leads to systemic inflammation, hormonal imbalances and an overactive immune system - all factors that contribute to the development of systemic diseases (McEwen & Wingfield, 2003).

* The fourth vicious cycle (dark red): is then additional stress experienced through HPA/ANS dysregulation itself, which in turn acts on your HPA/ANS system and (negative) neural configuration with all its consequences. Depending on stress (intensity) (for example: a lot is continuously expected of you, or you are an over performer because of your unsafe attachment or because of viral infections which are just a last drop for your overloaded system and because of your (partly hereditary) stress resistance and the other vicious circles a chronic self-sustaining system disorder arises.

Your body no longer gets the disturbances regulated. Chronic system diseases can result: long-term chronic (over)fatigue, Auto immune problems (low grade inflammation), Lung Covid, Lyme dysregulation, Chronic problems (Migraines, Depression & Anxieties, Phobias, Sleep problems), rapid overstimulation.

In summary, why do some people experience systemic diseases and others do not? Because of the combination and degree of (which therefore varies from person to person):

• (insecure) attachment, and related subconscious and suppressed or ever-compensated limiting negative beliefs and related behaviors (fleeing, pleasing, over performing, narcissism, attachment anxiety (bonding or separation anxiety) with your (unsafe) attachment or fate related (developmental) trauma (repressed emotions, held by your body in your fascia) and causing FAL dysregulation. 
• amplified internal stressors: learned (compensatory or suppressive) toxic life habits (addictions, narcotics, smoking, alcohol, unhealthy food(s patterns), or compensatory masking thoughts & behaviors: pleasing/over-performing in relationships or at work, buying frenzy, power, status and performance drives, theatrical behavior, ). These habits produce systemic stress.
• external stressors such as high workloads, demanding or personality disorders from supervisors, stressful life events (accidents, deaths, family and/or relationship problems) or viruses (Covid/Lyme/Q fever/or bacterial infections that eventually permanently overload your system stress.
• negative neuroplastic development (increased likelihood of stressful negative beliefs about yourself or others, and negative habits)
• HPA-ANS (chronic) dysregulation
• physiological damage sustained from regular excessive systemic stress
• DNA (predisposition) and epi-genetics (expression)

Actually, you could summarize: a combination of your childhood, work, relationship and social stress, bad luck, (toxic) habits, neuroplasticity, and your physical predisposition.

But unsafe attachment increases the likelihood of (experiencing) more stressful moments, lower internal stress tolerance and thus higher stress impact on your system throughout your life, and thus the likelihood of systemic diseases.

No wonder medicine doesn't have a ready-made answer for your recovery. Your system consists of a multitude of processes that can be dysregulated. The causes are diverse (and can be deep-seated) and the intensity/degree of physiological damage varies (blue arrow in image). So basically, systemic diseases are -spectrum disorders. You can have mild symptoms or life-altering symptoms.

In conclusion, people with systemic diseases regularly find themselves in social isolation and misunderstood by their surroundings. A systemic disease can also cause “physical” depression (shortage of certain substances), and despondency about a new orientation on “what can I still do”, or from compensatory behavior again an excess of activity / stress to just want to get better. With the result that your social contacts also decrease. Actually this is the fifth vicious circle: by (self) rejection and (self) condemnation and loss of social contacts and / or a multitude of advice and self-help part-treatments further (physical) depression and stress intensifies the systemic disease.

Searching for the Key to Recovery

After reading the above, we can conclude that part of chronic systemic diseases is modifiable and part is not. And that depending on intensity of system dysregulation and damage, (partial) recovery can be worked on. So there is perspective for the chronically ill.